Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis

Muller, IB; Lin, M; Lems, WF; ter Wee, MM; Wojtuszkiewicz, A; Nurmohamed, MT; Cloos, J; Assaraf, YG; Jansen, G; de Jonge, R

de Jonge, R (corresponding author), Univ Amsterdam, Dept Clin Chem, Med Ctr, VU Univ, Rm PK BRO20,De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.

RHEUMATOLOGY, 2021; 60 (3): 1273

Abstract

Objectives. An efficient pharmacological response to MTX treatment in RA patients relies on the retention and accumulation of intracellular MTX-polygl......

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