Nuclear SPHK2/S1P induces oxidative stress and NLRP3 inflammasome activation via promoting p53 acetylation in lipopolysaccharide-induced acute lung injury

Gong, LJ; Shen, Y; Wang, SJ; Wang, XY; Ji, HY; Wu, X; Hu, LJ; Zhu, L

Zhu, L (通讯作者),Fudan Univ, Zhongshan Hosp, Dept Pulm Med, Shanghai 200032, Peoples R China.;Zhu, L (通讯作者),Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Dept Resp & Crit Care Med, Beijing 102218, Peoples R China.

CELL DEATH DISCOVERY, 2023; 9 (1):

Abstract

A bulk of evidence identified that macrophages, including resident alveolar macrophages and recruited macrophages from the blood, played an important ......

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