Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

de Hoogd, S; Valitalo, PAJ; Dahan, A; van Kralingen, S; Coughtrie, MMW; van Dongen, EPA; van Ramshorst, B; Knibbe, CAJ

Knibbe, CAJ (reprint author), St Antonius Hosp, Dept Clin Pharm, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.; Knibbe, CAJ (reprint author), Leiden Univ, Leiden Acad Ctr Drug Res, Div Pharmacol, Leiden, Netherlands.

CLINICAL PHARMACOKINETICS, 2017; 56 (12): 1577

Abstract

Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the inf......

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