Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia

Jiang, C; Qian, MX; Gocho, Y; Yang, WT; Du, GQ; Shen, SH; Yang, J; Zhang, H

Zhang, H (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Hematol & Oncol, Sch Med, 1678 Dongfang Rd, Shanghai 200127, Peoples R China.;Yang, J (通讯作者)，St Jude Childrens Res Hosp, Dept Pharmaceut Sci, MS313,262 Danny Thomas Pi, Memphis, TN 38105 USA.;Zhang, H (通讯作者)，Fujian Childrens Hosp, Shanghai Childrens Med Ctr, Dept Hematol & Oncol, Fujian Branch, Fuzhou, Peoples R China.

BLOOD ADVANCES, 2022; 6 (8): 2496

Abstract

Epigenetic alterations, including histone acetylation, contribute to the malignant transformation of hematopoietic cells and disease progression, as w......

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