Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

Yuan, DJ; Yang, G; Wu, W; Li, QF; Xu, DE; Ntim, M; Jiang, CY; Liu, JC; Zhang, Y; Wang, YZ; Zhu, DD; Kundu, S; Li, AP; Xiao, ZC; Ma, QH; Li, S

Li, S (通讯作者)，Dalian Med Univ, Coll Basic Med Sci, Natl Local Joint Engn Res Ctr Drug Res & Dev R &, Dept Physiol,Liaoning Prov Key Lab Cerebral Dis, Dalian 116044, Liaoning, Peoples R China.;Ma, QH (通讯作者)，Soochow Univ, Dept Neurol, Affiliated Hosp 2, Suzhou 215123, Peoples R China.;Ma, QH (通讯作者)，Soochow Univ, Clin Res Ctr Neurol Dis, Affiliated Hosp 2, Suzhou 215123, Peoples R China.

AGING CELL, 2022; 21 (5):

Abstract

Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlyi......

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