Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency

Fry, LE; Peddle, CF; Stevanovic, M; Barnard, AR; McClements, ME; MacLaren, RE

Fry, LE (corresponding author), John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Level 6,West Wing, Oxford OX3 9DU, England.

CRISPR JOURNAL, 2020; 3 (4): 276

Abstract

Adeno-associated virus (AAV) vectors have been widely adopted for delivery of CRISPR-Cas components, especially for therapeutic gene editing. For a si......

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