Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds

Mao, JL; Ma, F; Yu, JS; De Bruyn, T; Ning, MR; Bowman, C; Chen, Y

Mao, JL; Chen, Y (通讯作者),Genentech Inc, Drug Metab & Pharmacokinet, South San Francisco, CA 94080 USA.

BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (4): 315

Abstract

The quantitative prediction of human pharmacokinetics (PK) including the PK profile and key PK parameters are critical for early drug development deci......

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