Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation

Lagarrigue, F; Gingras, AR; Paul, DS; Valadez, AJ; Cuevas, MN; Sun, H; Lopez-Ramirez, MA; Goult, BT; Shattil, SJ; Bergmeier, W; Ginsberg, MH

Ginsberg, MH (reprint author), Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.

BLOOD ADVANCES, 2018; 2 (18): 2358

Abstract

Activation of platelet glycoprotein IIb-IIIa (GPIIb-IIIa; integrin alpha IIb beta 3) leads to high-affinity fibrinogen binding and platelet aggregatio......

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