Intracellular angiopoietin-1 promotes TKI-resistance via activation of JAK/STAT5 pathway in chronic myeloid leukemia

Ma, D; Liu, P; Hu, CJ; Zhou, Z; Wang, P; Wang, Y; Zhang, YM; Ran, YS; Li, PH; Zhao, JY; Wang, JS; Zhang, CL; Tang, L

Wang, JS (通讯作者)，Guizhou Med Univ, Dept Hematol, Affiliated Hosp, Key Lab Hematol Dis Diagnost & Treat Ctr Guizhou, Guiyang 550004, Peoples R China.;Tang, L (通讯作者)，Guizhou Med Univ, Guizhou Prov Engn Technol Res Ctr Chem Drug R &, Guiyang 550004, Peoples R China.;Zhang, CL (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Hubei, Peoples R China.

ONCOGENE, 2023; 42 (2): 124

Abstract

Drug resistance from BCR-ABL tyrosine kinase inhibitors (TKIs) and other chemotherapeutics results in treatment failure and disease progression in chr......

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