Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Gao, FJ; Klinedinst, D; Fernandez, FX; Cheng, B; Savonenko, A; Devenney, B; Li, YC; Wu, D; Pomper, MG; Reeves, RH

Gao, FJ; Reeves, RH (corresponding author), Johns Hopkins Univ, Dept Physiol, Baltimore, MD 21205 USA.

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2021; 9 (1):

Abstract

Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence o......

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