Lessons from LIMK1 enzymology and their impact on inhibitor design

Salah, E; Chatterjee, D; Beltrami, A; Tumber, A; Preuss, F; Canning, P; Chaikuad, A; Knaus, P; Knapp, S; Bullock, AN; Mathea, S

Mathea, S (reprint author), Univ Oxford, Target Discovery Inst, Nuffield Dept Med, Roosevelt Dr, Oxford OX3 7FZ, England.; Bullock, AN; Mathea, S (reprint author), Univ Oxford, Struct Genom Consortium, Old Rd Campus,Roosevelt Dr, Oxford OX3 7DQ, England.;

BIOCHEMICAL JOURNAL, 2019; 476 (): 3197

Abstract

LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrom......

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