MCT4 blockade increases the efficacy of immune checkpoint blockade

Babl, N; Decking, SM; Voll, F; Althammer, M; Sala-Hojman, A; Ferretti, R; Korf, C; Schmidl, C; Schmidleithner, L; Nerb, B; Matos, C; Koehl, GE; Siska, P; Bruss, C; Kellermeier, F; Dettmer, K; Oefner, PJ; Wichland, M; Ugele, I; Bohr, C; Herr, W; Ramaswamy, S; Heinrich, T; Herhaus, C; Kreutz, M; Renner, K

Kreutz, M (通讯作者)，Univ Hosp Regensburg, Dept Internal Med 3, Regensburg, Germany.;Kreutz, M (通讯作者)，Leibniz Inst Immunotherapy, Regensburg, Germany.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023; 11 (10):

Abstract

Background & AimsIntratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the la......

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