Caspase-4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting gamma-secretase activity

Fan, LL; Liu, H; Zhu, GF; Singh, S; Yu, Z; Wang, SM; Luo, H; Liu, SY; Xu, YW; Ge, JB; Jiang, DY; Pang, JJ

Ge, JB; Jiang, DY (通讯作者)，Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol,Pan Vasc Res Inst, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.;Pang, JJ (通讯作者)，Univ Rochester, Aab Cardiovasc Res Inst, Dept Med & Dent, 601 Elmwood Ave, Rochester, NY 14642 USA.

BRITISH JOURNAL OF PHARMACOLOGY, 2022; 179 (20): 4809

Abstract

Background and Purpose: Notch1 activation mediated by gamma-secretase is critical for angiogenesis. GeneCards database predicted that Caspase-4 (CASP4......

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