Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study

Hong, ST; Su, YC; Wang, YJ; Cheng, TL; Wang, YT

Cheng, TL; Wang, YT (corresponding author), Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 80708, Taiwan.; Cheng, TL; Wang, YT (corresponding author), Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 80708, Taiwan.; Wang, YT (corresponding author), Kaohsiung Med Univ, Sch Postbaccalaureate Med, Coll Med, Kaohsiung 80708, Taiwan.; Wang, YT (corresponding author), Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80708, Taiwan.

BIOMOLECULES, 2021; 11 (2):

Abstract

Humira is a monoclonal antibody that binds to TNF alpha, inactivates TNF alpha receptors, and inhibits inflammation. Neonatal Fc receptors can mediate......

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