Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC

Xiao, JJ; Zhang, L; Yi, HJ; Zou, L; Mo, JM; Xue, F; Zheng, JH; Huang, YZ; Lu, H; Wu, HS; Xue, PP; Zhang, X; He, LF; Li, ZX; Pang, SG; Qiao, GB; Duan, QH; Zhu, F

Xiao, JJ; Zhu, F (通讯作者)，Guilin Med Univ, Canc Res Inst, Affiliated Hosp, Guilin 541001, Guangxi, Peoples R China.;Xiao, JJ; Zhu, F (通讯作者)，Guilin Med Univ, Guangxi Hlth Commiss Key Lab Novel Onco Kinases T, Affiliated Hosp, Guilin 541001, Guangxi, Peoples R China.;Xiao, JJ; Duan, QH (通讯作者)，Huazhong Univ Sci & Technol, Sch Basic Med, Dept Biochem & Mol Biol, Wuhan 430030, Hubei, Peoples R China.;Qiao, GB (通讯作者)，Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Thorac Surg, Guangzhou 510080

CELL DEATH & DISEASE, 2022; 13 (9):

Abstract

T-LAK cell-oriented protein kinase (TOPK) is a potential therapeutic target in tumors. However, its role in anaplastic lymphoma kinase (ALK)-positive ......

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