Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules

Sun, JC; Prabhu, N; Tang, J; Yang, F; Jia, L; Guo, JA; Xiao, KF; Tam, WL; Nordlund, P; Dai, LY

Dai, LY (corresponding author), Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Urol, Shenzhen 518020, Guangdong, Peoples R China.; Dai, LY (corresponding author), Southern Univ Sci & Technol, Shenzhen Urol Minimally Invas Engn Ctr, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.; Nordlund, P (corresponding author), ASTAR, Inst Mol & Cell Biol, Singapore 138673, Singapore.; Tam, WL (corresponding author), ASTAR, Genome Inst Singapore, Singapore 138672, Singapore.

MEDICINAL RESEARCH REVIEWS, ; ():

Abstract

Small-molecule drugs modulate biological processes and disease states through engagement of target proteins in cells. Assessing drug-target engagement......

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