Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis

Beppu, LY; Mooli, RGR; Qu, XY; Marrero, GJ; Finley, CA; Fooks, AN; Mullen, ZP; Frias, AB; Sipula, I; Xie, BX; Helfrich, KE; Watkins, SC; Poholek, AC; Ramakrishnan, SK; Jurczak, MJ; D'Cruz, LM

D'Cruz, LM (corresponding author), Univ Pittsburgh, Dept Immunol, Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15213 USA.

JCI INSIGHT, 2021; 6 (3):

Abstract

Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress inflammation. Paradoxically, immune cell-derived IL-10 can drive insuli......

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