TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

Zuo, XX; Zhou, J; Li, YM; Wu, K; Chen, ZG; Luo, ZW; Zhang, XR; Liang, Y; Esteban, MA; Zhou, Y; Fu, XD

Zhou, Y (corresponding author), Wuhan Univ, Coll Life Sci, State Key Lab Virol, Hubei Key Lab Cell Homeostasis, Wuhan, Peoples R China.; Zhou, Y (corresponding author), Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Wuhan, Peoples R China.; Fu, XD (corresponding author), Univ Calif San Diego, Inst Genom Med, Dept Cellular & Mol Med, San Diego, CA 92093 USA.

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (2): 132

Abstract

Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative stress when it was first linked to mutant superoxide dismuta......

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