Proteolysis-targeting chimera molecules targeting SHP2

Yu, DD; Zheng, MZ; Liu, Y; Chen, LX; Li, H

Li, H (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Rongcheng Ctr Biomed, Sch Pharm,Hubei Key Lab Nat Med Chem & Resource E, Wuhan 430030, Peoples R China.;Chen, LX; Li, H (通讯作者)，Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.

FUTURE MEDICINAL CHEMISTRY, 2022; 14 (8): 587

Abstract

SHP2 is a member of the non-receptor protein tyrosine phosphatases, encoded by PTPN11, and exhibits oncogenic activities. The close association betwee......

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