OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1 alpha during hypoxia adaptation

Liu, X; Deng, HY; Tang, JH; Wang, ZX; Zhu, CC; Cai, XL; Rong, FJ; Chen, XY; Sun, XY; Jia, SK; Ouyang, G; Li, WH; Xiao, WH

Xiao, WH (通讯作者)，Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.;Xiao, WH (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;Xiao, WH (通讯作者)，Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China.;Xiao, WH (通讯作者)，Hubei Hongshan Lab, Wuhan 430070, Peoples R China.;Li, WH (通讯作者)，Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China.;Li, WH (通讯作者)，Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072

CELL DEATH & DISEASE, 2022; 13 (6):

Abstract

As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-inducible factor (HIF)-1 alpha is strictly controlled by oxygen......

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