Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Goetz, MP; Sangkuhl, K; Guchelaar, HJ; Schwab, M; Province, M; Whirl-Carrillo, M; Symmans, WF; McLeod, HL; Ratain, MJ; Zembutsu, H; Gaedigk, A; van Schaik, RH; Ingle, JN; Caudle, KE; Klein, TE

Goetz, MP (reprint author), Mayo Clin, Dept Oncol, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA.

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018; 103 (5): 770

Abstract

Tamoxifen is biotransformed by CYP2D6 to 4-hydroxytamoxifen and 4-hydroxy N-desmethyl tamoxifen (endoxifen), both with greater antiestrogenic potency ......

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