Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses

Greaney, SK; Algazi, AP; Tsai, KK; Takamura, KT; Chen, L; Twitty, CG; Zhang, L; Paciorek, A; Pierce, RH; Le, MH; Daud, AI; Fong, L

Fong, L (corresponding author), Univ Calif San Francisco, 513 Parnassus Ave,Room HSE301A, San Francisco, CA 94143 USA.; Daud, AI (corresponding author), Univ Calif San Francisco, 550 16th St,Room MS6809, San Francisco, CA 94158 USA.

CANCER IMMUNOLOGY RESEARCH, 2020; 8 (2): 246

Abstract

Whereas systemic IL12 is associated with potentially life-threatening toxicity, intratumoral delivery of IL12 through tavoki-nogene telseplasmid elect......

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