Discovery and optimization of covalent Bcl-xL antagonists

Mukherjee, H; Su, N; Belmonte, MA; Hargreaves, D; Patel, J; Tentarelli, S; Aquila, B; Grimster, NP

Grimster, NP (reprint author), AstraZeneca, Oncol R&D, Waltham, MA 02451 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019; 29 (23):

Abstract

Over the last ten years, targeted covalent inhibition has become a key discipline within medicinal chemistry research, most notably in the development......

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