The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions

Ahmed, SM; Ragunathan, P; Shin, J; Peter, S; Kleissle, S; Neuenschwander, M; Schäfer, R; Kries, JPV; Grüber, G; Dröge, P

Dröge, P (通讯作者)，Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.

FEBS LETTERS, 2023; 597 (15): 1977

Abstract

The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is ......

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