Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis

Liu, Y; Li, YP; Xiao, LM; Chen, LK; Zheng, SY; Zeng, EM; Xu, CH

Xu, CH (corresponding author), Nanchang Univ, Affiliated Hosp 1, Dept Neurosurg, Nanchang, Jiangxi, Peoples R China.

LABORATORY INVESTIGATION, 2021; 101 (7): 837

Abstract

M2 microglia-derived EVs inhibit neuronal autophagic activity. Mechanistically, M2 microglia-derived EVs deliver miR-135a-5p into neuronal cells to in......

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