Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis

Chen, Z; Huo, DW; Li, L; Liu, ZL; Li, ZG; Xu, SN; Huang, YX; Wu, WR; Zhou, CF; Liu, YY; Kuang, M; Wu, F; Li, H; Qian, PX; Song, GB; Wu, XD; Chen, JP; Hou, Y

Chen, JP; Hou, Y (corresponding author), Third Mil Med Univ, Army Med Univ, Dept Hematol, Southwest Hosp, Chongqing, Peoples R China.; Wu, XD (corresponding author), Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet 2011, Dept Cell Biol, Tianjin Key Lab Med Epigenet, Tianjin, Peoples R China.

JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (5):

Abstract

The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secret......

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