Inhibiting Src-mediated PARP1 tyrosine phosphorylation confers synthetic lethality to PARP1 inhibition in HCC

Sun, CY; Jing, WQ; Xiong, GZ; Ma, DP; Lin, YK; Lv, XT; Zhao, YX; Ma, XM; Zhu, LH; Shen, XC; Yang, M; Qin, ZZ; Cheng, YP; Xuan, HC; Li, T; Han, LH

Han, LH (通讯作者)，Shandong Univ, Cheeloo Coll Med, Shandong Prov Key Lab Infect & Immunol, Sch Basic Med Sci,Dept Immunol, Jinan 250012, Shandong, Peoples R China.

CANCER LETTERS, 2022; 526 (): 180

Abstract

Hepatocellular carcinoma (HCC), a heterogeneous cancer with high mortality, is resistant to single targeted therapy; thus, combination therapy based o......

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