Structure-Activity Relationship Investigation on Reaction Mechanism between Chlorinated Quinoid Carcinogens and Clinically-Used Aldoxime Nerve-Agent Antidote under Physiological Condition

Xie, LN; Huang, CH; Xu, D; Qin, L; Li, F; Shan, GQ; Liu, ZS; Cao, D; Geng, FL; Mao, L; Shao, J; Sheng, ZG; Zhu, BZ

Zhu, BZ (corresponding author), Univ Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China.; Zhu, BZ (corresponding author), Res Ctr Ecoenvironm Sci, Joint Inst Environm Sci, Beijing, Peoples R China.; Zhu, BZ (corresponding author), Hong Kong Baptist Univ, Hong Kong, Peoples R China.

CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (4): 1091

Abstract

Pyridinium aldoximes are best-known therapeutic antidotes used for clinical treatment of poisonings by organophosphorus nerve-agents and pesticides. R......

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