WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

Lu, CW; Liu, ZQ; Klement, JD; Yang, DF; Merting, AD; Poschel, D; Albers, T; Waller, JL; Shi, HD; Liu, KB

Lu, CW (corresponding author), Tianjin Univ, Sch Life Sci, Tianjin, Peoples R China.; Liu, KB (corresponding author), Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA.; Liu, KB (corresponding author), Med Coll Georgia, Georgia Canc Ctr, Augusta, GA 30912 USA.; Liu, KB (corresponding author), Charlie Norwood VA Med Ctr, Augusta, GA 30904 USA.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7):

Abstract

Background Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor cells and cytotoxic T lymphocytes tumor infiltration in the tumor mi......

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