Recombinant Factor VIII Fc Inhibits B Cell Activation via Engagement of the Fc gamma RIIB Receptor

Georgescu, MT; Moorehead, PC; Liu, TY; Dumont, J; Scott, DW; Hough, C; Lillicrap, D

Lillicrap, D (corresponding author), Queens Univ, Dept Pathol & Mol Med, Clin & Mol Hemostasis Res Grp, Kingston, ON, Canada.

FRONTIERS IN IMMUNOLOGY, 2020; 11 ():

Abstract

The development of neutralizing antibodies (inhibitors) against factor VIII (FVIII) is a major complication of hemophilia A treatment. The sole clinic......

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