A Physiologically-Based Pharmacokinetic Model of Methotrexate Incorporating Hepatic Excretion via Multidrug-Resistance-Associated Protein 2 (Mrp2) in Mice, Rats, Dogs, and Humans

Lohitnavy, M; Lu, YS; Lohitnavy, O; Yang, RSH

Lohitnavy, M (reprint author), Naresuan Univ, Ctr Excellence Environm Hlth & Toxicol, Phitsanulok 65000, Thailand.; Lohitnavy, M (reprint author), Naresuan Univ, Fac Pharmaceut Sci, Dept Pharm Practice, Pharmacokinet Res Unit, Phitsanulok 65000, Thailand.

2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2017; ( ): 2728

Abstract

An updated physiologically-based pharmacokinetic (PBPK) model of methotrexate (MTX) was built based on an earlier model developed by Bischoff et al. (......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索