Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2

Dong, JN; Li, S; Liu, GX

Dong, JN (corresponding author), China Med Univ, Liaoning Canc Hosp & Inst, Dept Pharm, Canc Hosp, Shenyang 110042, Peoples R China.

CHEMICAL RESEARCH IN TOXICOLOGY, 2021; 34 (4): 1169

Abstract

Binimetinib is a selective MEK1/2 inhibitor, which is indicative of melanoma. We aimed to investigate the inhibitory effect of binimetinib on cytochro......

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