Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4

Hou, XL; Zhang, XX; Zou, H; Guan, MF; Fu, CY; Wang, WY; Zhang, ZR; Geng, Y; Chen, YL

Geng, Y; Chen, YL (通讯作者)，Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, 100 Haike Rd,B13,Pudongxinqu, Shanghai 201210, Peoples R China.

NEURON, 2023; 111 (12):

Abstract

Aberrant low y-secretase activity is associated with most of the presenilin mutations that underlie familial Alz-heimer's disease (fAD). However, the ......

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