Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

Kelso, S; O'Brien, S; Kurinov, I; Angers, S; Sicheri, F

Sicheri, F (通讯作者)，Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.;Sicheri, F (通讯作者)，Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.;Angers, S; Sicheri, F (通讯作者)，Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.;Angers, S (通讯作者)，Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 1A8, Canada.;Angers, S (通讯作者)，Univ Toronto, Leslie & Fac Pharm, Toronto, ON M5S 3M2, Canada.

STRUCTURE, 2022; 30 (12): 1615

Abstract

CDK11 is a cyclin-dependent kinase that controls proliferation by regulating transcription, RNA splicing, and the cell cycle. As its activity is incre......

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