Macrophage-specific hypoxia-inducible factor-1 alpha deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice

Takkawa, A; Usui, I; Fujisaka, S; Tsuneyama, K; Okabe, K; Nakagawa, T; Nawaz, A; Kado, T; Jojima, T; Aso, Y; Hayakawa, Y; Yagi, K; Tobe, K

Usui, I (reprint author), Univ Toyama, Dept Internal Med 1, Toyama, Japan.; Usui, I (reprint author), Dokkyo Med Univ, Dept Endocrinol & Metab, Mibu, Tochigi, Japan.

JOURNAL OF DIABETES INVESTIGATION, 2019; 10 (6): 1411

Abstract

Aims/Introduction Chronic inflammation of the liver is often observed with obesity or type 2 diabetes. In these pathological conditions, the immunolog......

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