Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth

Della Monica, R; Buonaiuto, M; Cuomo, M; Pagano, C; Trio, F; Costabile, D; de Riso, G; Cicala, FS; Raia, M; Franca, RA; De Caro, MD; Sorrentino, D; Navarra, G; Coppola, L; Tripodi, L; Pastore, L; Hench, J; Frank, S; Schonauer, C; Catapano, G; Bifulco, M; Chiariotti, L; Visconti, R

Della Monica, R; Chiariotti, L; Visconti, R (通讯作者)，CEINGE Adv Biotechnol Franco Salvatore, Naples, Italy.;Della Monica, R; Chiariotti, L (通讯作者)，Univ Napoli Feder II, Dept Mol Med & Med Biotechnol, Naples, Italy.;Visconti, R (通讯作者)，Natl Council Res Italy, Inst Expt Endocrinol & Oncol G Salvatore, Naples, Italy.

CELL DEATH & DISEASE, 2023; 14 (9):

Abstract

Despite intense research efforts, glioblastoma remains an incurable brain tumor with a dismal median survival time of 15 months. Thus, identifying new......

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