A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia

Zeidan, AM; Ridinger, M; Lin, TL; Becker, PS; Schiller, GJ; Patel, PA; Spira, AI; Tsai, ML; Samuelsz, E; Silberman, SL; Erlander, M; Wang, ES

Zeidan, AM (corresponding author), Yale Univ, 333 Cedar St,POB 208028, New Haven, CT 06520 USA.

CLINICAL CANCER RESEARCH, 2020; 26 (23): 6132

Abstract

Purpose: The Polo-like kinase 1 (PLK1) is a master regulator of mitosis and overexpressed in acute myeloid leukemia (AML). We conducted a phase Ib stu......

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