Diastereoselective FeCl3 center dot 6H(2)O/NaBH4 Reduction of Oxime Ether for the Synthesis of beta-Lactamase Inhibitor Relebactam

Chung, JYL; Meng, DF; Shevlin, M; Gudipati, V; Chen, QH; Liu, YZ; Lam, YH; Dumas, A; Scott, J; Tu, Q; Xu, F

Chung, JYL; Meng, DF (corresponding author), Merck & Co Inc, Proc Res & Dev, Rahway, NJ 07065 USA.

JOURNAL OF ORGANIC CHEMISTRY, 2020; 85 (2): 994

Abstract

Relebactam, a potent beta-lactamase inhibitor, in combination with Primaxin is an FDA-approved (Recarbrio) treatment for serious and antibiotic-resist......

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