Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1 alpha stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment

Feng, JB; Zhang, Y; She, XL; Sun, YN; Fan, L; Ren, X; Fu, HJ; Liu, CH; Li, PY; Zhao, CH; Liu, Q; Liu, Q; Li, GY; Wu, MH

Wu, MH (reprint author), Cent S Univ, Hunan Prov Tumor Hosp, Changsha 410013, Hunan, Peoples R China.; Wu, MH (reprint author), Cent S Univ, Affiliated Tumor Hosp, Xiangya Med Sch, Changsha 410013, Hunan, Peoples R China.; Wu, MH (reprint author), Cent S

ONCOGENE, 2019; 38 (1): 103

Abstract

Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppr......

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