Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

Li, YZ; Su, ZJ; Zhao, WY; Zhang, XF; Momin, N; Zhang, CX; Wittrup, KD; Dong, YZ; Irvine, DJ; Weiss, R

NATURE CANCER, 2020; 1 (9): 882

Abstract

Therapies that synergistically stimulate immunogenic cancer cell death (ICD), inflammation and immune priming are of great interest for cancer immunot......

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