Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB

Wei, J; Shi, ZQ; Na, R; Resurreccion, WK; Wang, CH; Duggan, D; Zheng, SL; Hulick, PJ; Helfand, BT; Xu, JF

Xu, JF (通讯作者),NorthShore Univ HealthSyst, Program Personalized Canc Care, Evanston, IL 60201 USA.

JOURNAL OF MEDICAL GENETICS, 2022; 59 (3): 243

Abstract

Background SNP-based polygenic risk scores have recently been adopted in the clinic for risk assessment of some common diseases. Their validity is sup......

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