OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

Fu, YS; Wang, HT; Dai, HM; Zhu, Q; Cui, CP; Sun, XX; Fu, YS; Li, YC; Deng, ZK; Wang, HT; Zhou, XM; Ge, YW; Peng, ZQ; Yuan, C; Wu, B; Yang, X; Li, RY; Liu, CH; He, FC; Wei, WY; Zhang, LQ

He, FC; Zhang, LQ (corresponding author), Beijing Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 100850, Peoples R China.; He, FC (corresponding author), Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China.; Liu, CH (corresponding author), Univ Chinese Acad Sci, Savaid Med Sch, Inst Microbiol Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China.; Wei, WY (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept

MOLECULAR CELL, 2021; 81 (15): 3187

Abstract

OTULIN coordinates with LUBAC to edit linear polyubiquitin chains in embryonic development, autoimmunity, and inflammatory diseases. However, the mech......

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