Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas

Whitson, RJ; Lee, A; Urman, NM; Mirza, A; Yao, CY; Brown, AS; Li, JR; Shankar, G; Fry, MA; Atwood, SX; Lee, EY; Hollmig, ST; Aasi, SZ; Sarin, KY; Scott, MP; Epstein, EH; Tang, JY; Oro, AE

Oro, AE (reprint author), Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA USA.; Oro, AE (reprint author), Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA USA.

NATURE MEDICINE, 2018; 24 (3): 271

Abstract

Hedgehog pathway-dependent cancers can escape Smoothened (SMO) inhibition through mutations in genes encoding canonical hedgehog pathway components; h......

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