Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

Lee, BDM; Harold, LK; Almeida, DV; Afriat-Jurnou, L; Aung, HL; Forde, BM; Hards, K; Pidot, SJ; Ahmed, FH; Mohamed, AE; Taylor, MC; West, NP; Stinear, TP; Greening, C; Beatson, SA; Nuermberger, EL; Cook, GM; Jackson, CJ

Jackson, CJ (corresponding author), Australian Natl Univ, Res Sch Chem, Canberra, ACT, Australia.

PLOS PATHOGENS, 2020; 16 (2):

Abstract

Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, ......

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