Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging

Yu, Y; Song, XY; Wang, XX; Zheng, LX; Ma, GJ; Liu, WW; Su, H; Liu, XY; Liu, TT; Cao, L; Wang, DF

Cao, L (通讯作者)，China Med Univ, Hlth Sci Inst, Shenyang, Peoples R China.;Wang, DF (通讯作者)，China Med Univ, Dept Gerontol, Shengjing Hosp, Shenyang 110004, Peoples R China.

AGING CELL, 2023; 22 (5):

Abstract

Sirt1 is an NAD(+)-dependent deacetylase that protects against premature aging and cell senescence. Aging accompanied by oxidative stress leads to a d......

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