Menadione inhibits thioredoxin reductase 1 via arylation at the Sec(498) residue and enhances both NADPH oxidation and superoxide production in Sec(498) to Cys(498) substitution

Sun, SB; Xu, WP; Zhang, Y; Yang, YJ; Ma, Q; Xu, JQ

Xu, JQ (corresponding author), Dalian Univ Technol, Sch Life & Pharmaceut Sci LPS, Panjin 124221, Peoples R China.; Xu, JQ (corresponding author), Dalian Univ Technol, Panjin Inst Ind Technol PIIT, Panjin 124221, Peoples R China.; Ma, Q (corresponding author), Chinese Acad Inspect & Quarantine, Beijing 100176, Peoples R China.

FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 (): 482

Abstract

The selenoprotein thioredoxin reductase 1 (TrxR1; TXNRD1) participates in multiple cellular processes and is regarded as a cellular target in anti-tum......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索