Prostaglandin E-2 in a TLR3-and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8(+) T cells

Gierlich, P; Lex, V; Technau, A; Keupp, A; Morper, L; Glunz, A; Sennholz, H; Rachor, J; Sauer, S; Marcu, A; Grigoleit, GU; Wolfl, M; Schlegel, PG; Eyrich, M

Eyrich, M (corresponding author), Childrens Hosp, Lab Stem Cell Proc & Cellular Therapy Univ Med Ct, Wurzburg, Germany.; Eyrich, M (corresponding author), Univ Childrens Hosp Wurzburg, Josef Schneider Str 3,Bldg D30, D-97080 Wurzburg, Germany.

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2020; 69 (6): 1029

Abstract

Mature dendritic cells (DCs) represent cellular adjuvants for optimal antigen presentation in cancer vaccines. Recently, a combination of prostaglandi......

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