PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth

Chen, S; Chen, JW; Du, WT; Mickelsen, DM; Shi, HC; Yu, H; Kumar, S; Yan, C

Chen, S; Yan, C (通讯作者)，Univ Rochester, Cardiovasc Res Inst, Sch Med & Dent, Rochester, NY 14642 USA.

CIRCULATION RESEARCH, 2023; 133 (2): 138

Abstract

Background:Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP......

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