Sirt1 Protects Subventricular Zone-Derived Neural Stem Cells from DNA Double-Strand Breaks and Contributes to Olfactory Function Maintenance in Aging Mice

Ren, J; Wang, XL; Dong, CM; Wang, GM; Zhang, WJ; Cai, CH; Qian, MX; Yang, DJ; Ling, B; Ning, K; Mao, ZY; Liu, BH; Wang, TH; Xiong, LL; Wang, WY; Liang, AB; Gao, ZL; Xu, J

Xu, J (通讯作者)，Tongji Univ, East Hosp, Sch Med, Shanghai 200120, Peoples R China.;Liang, AB (通讯作者)，Tongji Univ, Dept Hematol, Tongji Hosp, Sch Med, Shanghai 200065, Peoples R China.;Gao, ZL (通讯作者)，Tongji Univ, Sch Med, Shanghai Sunshine Rehabil Ctr, Yangzhi Rehabil Hosp, Shanghai 201619, Peoples R China.;Wang, WY (通讯作者)，Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China.

STEM CELLS, 2022; 40 (5): 493

Abstract

DNA damage is assumed to accumulate in stem cells over time and their ability to withstand this damage and maintain tissue homeostasis is the key dete......

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