Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation

Müller, F; Lim, JKM; Bebber, CM; Seidel, E; Tishina, S; Dahlhaus, A; Stroh, J; Beck, J; Yapici, FI; Nakayama, K; Fernández, LT; Brägelmann, J; Leprivier, G; von Karstedt, S

von Karstedt, S (通讯作者)，Univ Cologne, Fac Med, Cologne, Germany.;von Karstedt, S (通讯作者)，Univ Cologne, Univ Hosp Cologne, Dept Translat Genom, Cologne, Germany.;von Karstedt, S (通讯作者)，Univ Cologne, CECAD Cluster Excellence, Cologne, Germany.;von Karstedt, S (通讯作者)，Univ Cologne, Ctr Mol Med Cologne, Univ Hosp Cologne, Cologne, Germany.

CELL DEATH AND DIFFERENTIATION, 2023; 30 (2): 442

Abstract

Oncogenic KRAS is the key driver oncogene for several of the most aggressive human cancers. One key feature of oncogenic KRAS expression is an early i......

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